I Have Been Trying To Get Pregnant For Over A Year, When Should I Consider In Vitro Fertilization (IVF)?

Does it seem like awhile that you have been trying to get pregnant to no avail?  Sher Fertility Institute New York’s fertility expert, Sergio Oehninger, MD, PhD, will discuss when you should think about when considering IVF in his latest blog.

IVF is an established and standard therapy and is the most efficient alternative to achieve a pregnancy in each female cycle. Women under the age of 35 should seek help from reproductive specialists after one year of trying, while women over the age of 35 should consult before. IVF will be offered if: early and simple interventions have failed (such as ovulation stimulation, intrauterine inseminations -IUI-) after three attempts, or as an initial approach if the underlying cause is serious to justify IVF.

Almost all female and male pathologies can be successfully treated by IVF. These include:

  • tubal factors
  • endometriosis
  • Ovulation dysfunctions
  • recurrent loss of pregnancy
  • male infertility.

Why is IVF so successful?

In IVF women undergo controlled hormonal ovarian stimulation that results in the removal of mature, fertilizable eggs (egg retrieval). Immediately, the eggs are fertilized with the partner’s sperm, and the resulting embryos are cultured in the incubators for 5 days until the blastocyst stage. At that time, a single blastocyst can be transferred to the uterus, while the remaining embryos are frozen for future use. This approach provides multiple pregnancy attempts, thus further increasing the probability of success (cumulative pregnancy rate). IVF avoids the negative effects of tubal disease and endometriosis and helps sperm to fertilize eggs even in the presence of low sperm parameters.

What factors affect IVF success?

First and foremost, the age of the woman and her ovarian reserve. The IVF pregnancy rate per embryo transfer in women 35 years and under is 45-55%, whereas in women 36-42 years is 25-40%. Women that can freeze extra embryos can reach a 60% cumulative pregnancy rate following multiple frozen embryo transfers (FET).

Second, it is critical to investigate and correct the presence of uterine factors (polyps, fibroids) that can affect implantation.

Can I know the chromosomal status and sex of the embryos?

Yes!!! The blastocysts can be subjected to a so-called embryo biopsy, a process named preimplantation genetic screening (PGS). With this micromanipulation a few cells are extracted from the blastocyst and analyzed for DNA normalcy, with high safety and accuracy. Following the transfer of a chromosomally normal (euploid) blastocyst the pregnancy rate (live birth rate) can reach an outstanding 55-60%.  Very importantly, we are moving to a non-invasive method that analyzes cell-free DNA in the fluid surrounding the embryo during culture. This novel procedure may result in even higher pregnancy rates!!

If you want are considering an IVF journey please contact Sher Fertility Institute New York at 646-792-7476 or click here to  schedule an appointment with one of our fertility doctors .  We will guide you through the financial and medical aspects of IVF, so that you can maximize your chances to get pregnant.